Lactobacillus Side Effects
If you consider taking Lactobacillus for diarrhea, you may be wondering whether it has any side effects. The answer to this question depends on your situation. The probiotic bacteria found in Lactobacillus products help restore intestinal flora, increase GABA levels and even reduce Escherichia coli populations. However, there are some side effects to Lactobacillus that you need to be aware of.
It helps treat diarrhea.
Studies have shown that Lactobacillus helps treat diarrhea by reducing the levels of certain neurobiological factors. The strains CCFM1143 and LPS have strong adhesive properties and adhere to human ileal cells. These bacteria have been linked to severe gastrointestinal complications, including abscesses and meningitis. However, these effects were not consistent across cultures. This suggests that Lactobacillus helps treat diarrhea and protects against other infections caused by the same bacteria.
Researchers have concluded that Lactobacillus may help prevent and treat diarrhea caused by viral agents. The most common agent of acute diarrhea in children worldwide is rotavirus. A Cochrane database compiled pooled estimates of the effect of Lactobacillus on acute rotavirus diarrhea. This research shows that Lactobacillus may help prevent or treat diarrhea in children. But more research needs to be done before recommending it as a safe, effective treatment.
One type of functional diarrhea is called functional diarrhea, and it causes chronic bouts of diarrhea. Research has shown that Lactobacillus can help alleviate this disease in mice. Specifically, Lactobacillus Plantarum CCFM1143 can relieve chronic diarrhea induced by ETEC. Another study examined the effects of CCFM1143 on chronic diarrhea patients. In this study, 55 patients with chronic diarrhea were randomly assigned to one of two groups: a group that received CCFM1143 while the other group received their usual regimen.
It restores intestinal flora.
Intestinal flora is vital for optimal health. In the absence of proper gut flora, we become susceptible to illnesses. To re-establish the proper balance, we must eat various fruits and vegetables, which are rich in beneficial bacteria. Some sources of beneficial bacteria include resistant starches and legumes, which ferment in the intestines. A well-populated gut lining supports the growth of healthy bacteria.
The probiotic bacterium L. reuteri in the intestine is associated with several beneficial effects. This bacterium is associated with reduced pro-inflammatory cytokines and increased production of regulatory T cells. It also strengthens the intestine barrier and decreases microbial translocation. These properties may explain the association between an increased abundance of L. reuteri and improved inflammatory health.
The human intestine contains many colony-forming units (CFUs). These bacteria are present in our vagina and intestine and protect us against bad bacteria. While a person’s intestinal flora is highly varied, a healthy balance is essential for good health. There are colonies of beneficial bacteria in our digestive tract that help us digest food and fight against bad bacteria. If our bodies do not have enough CFU, we experience digestive problems and other illnesses.
Supplementing with Lactobacillus may also improve the immune system. In some studies, supplementation of Lactobacillus helped reduce the duration of antibiotic treatment and the number of days missing school. Moreover, it also reduced the incidence of childhood eczema and pollen allergies. In addition, it improved the immune response, reducing the severity and frequency of occurrence of the disease.
It increases GABA levels.
A new study shows that taking Lactobacillus regularly can improve insulin sensitivity and glucose tolerance in metabolically dysfunctional mice. Researchers used two strains of L. brevis, which produce GABA, to study their potential therapeutic effects in a mouse model of diet-induced obesity. The strains differ in their efficiency of GABA biosynthesis, but both showed significant improvements in insulin sensitivity.
There are many potential benefits of modifying the microbiota of the gastrointestinal tract. One of these is the modulation of abnormal behavior and metabolic dysfunction by microbial GABA production. These changes are particularly beneficial in obesity and metabolic dysfunction, associated with several health problems. These changes in microbiota can also impact insulin levels and behavior. However, further substantiation is needed before the benefits of Gut Biota Modification can be considered clinically relevant.
The production of GABA by LAB strains has been linked to various factors, including higher transcriptional activation. The DSM 32386 strain showed 200% higher GABA production than the type strain in the laboratory. Researchers also noted that Lactobacillus brevis exhibited similar performance under stress conditions of the gastrointestinal tract. Further, this strain can grow in an acidic environment and increase GABA levels in simulated pancreatic fluid and 0.3% ox-bile.
It increases the Escherichia coli population.
In this study, L. casei was embedded in micro-scale clusters of E. coli during the early growth phase. The authors describe how lactobacillus strains can grow in a minimal medium near co-cultured bacteria. These findings indicate that the presence of Lactobacillus is beneficial for the growth of Escherichia coli.
The bacterial population enters a logarithmic phase, in which the number of cells increases in equal intervals. This ensures balanced growth until the nutrient source runs out or toxic products accumulate. At that point, cell growth slows, and some may die. The maximum population reaches 10 to 30 billion cells per milliliter. Further studies are needed to confirm that Lactobacillus is beneficial.
In a study, L. acidophilus induced T-helper-1 cytokines without pathogen challenge. In chicken spleens, L. salivarius increases the transcription of cytokines. In another study, L. Plantarum strain P-8 increases transcription in jejunal cells. This result was reported 14 days after the treatment. The findings of this study indicate that Lactobacillus is beneficial for reducing the population of Escherichia coli.
The bacterial species L. rhamnosus IMC 501 and L. paracasei IMC 502 exhibit different adhesion properties. They also show antimicrobial activity against different Candida strains. In addition, Parolin et al. (2015) found that L. rhamnosus strains have different adhesive properties. The most adherent strains were L. crispatus BC1 and L. gasseri BC8. Mucus-binding proteins mediate the adhesion to the cells.
It prevents Leaky Gut Syndrome.
Research has demonstrated that a bacterial strain called Lactobacillus can help prevent Leaky Gut Syndrome. This condition is characterized by intestinal permeability, whereby partially digested food particles enter the bloodstream. The immune system can respond to this by producing symptoms that include digestive complaints, fatigue, joint pain, and food sensitivities. Although the exact cause of the leaky gut syndrome remains unknown, it has been widely recognized in the scientific literature.
The bacteria responsible for maintaining a healthy intestinal flora are called Lactobacillus. These microbes have several beneficial effects, including lowering serum cholesterol levels and improving lactose metabolism. Several strains of Lactobacillus have immunomodulatory effects and are involved in various physiological and biochemical functions. The bacteria have an ideal pH of 6.7 and are found in nearly every healthy person’s gut. They also have anti-inflammatory and immune-modulatory properties.
Inflammation damages the villi of the enterocytes, which are responsible for digestion—inflammation results in a decrease in the production of these enzymes. As a result, carbohydrates are flushed to the lower intestine, where they are metabolized by pathogenic bacteria. Eventually, the gut can become severely damaged, leading to leaky GI symptoms. As a result, dietary changes and probiotics are needed to correct the problem.
It reduces H pylori infection.
The presence of Lactobacillus in the stomach mucous layer may reduce the occurrence of Helicobacter pylori infection. The organism lives in the stomach and duodenum and affects a large proportion of the population, 51% of which are carriers. Inflammation of the gastric mucus layer, known as atrophic gastritis, is one of the symptoms of H pylori colonization. The organism itself may increase the risk for peptic ulcers and gastric cancer.
Several studies have shown that a mixture of Lactobacillus and H. pylori reduces the infection by preventing the bacteria from attaching to the epithelium. This effect is not dependent on the pH of the stomach or the presence of other bacteria. Inhibitory lactobacilli prevent H. pylori from attaching to the stomach epithelial cells.
The effects of Lactobacillus supplementation on H pylori infections were not different in the two groups. There were no significant differences in the incidence of side effects in the Lactobacillus group compared with the eradication group. Furthermore, there was no difference in eradication rates between the two groups, indicating that both treatments were equally effective.
Standard eradication therapy protocols have significant side effects, with a high failure rate. Further, due to low compliance, antibiotic therapy may have adverse effects. However, probiotics have been shown to lessen the severity of these side effects while increasing the overall eradication rate. Both antibiotics and probiotics have been used as a single therapy concurrently with standard eradication therapy.