Lactobacillus Plantarum and Irritable Bowel Syndrome
Phylogenetic studies placedlactobacillus plantarium in the Lactobacillus casei-Pediococcus group, but DNA-DNA hybridization has demonstrated that the strains are related at least 50-60%. Phylogenetic studies have also shown that Lb. Plantarum is not related to any other strep bacterial species. However, it is often characterized as having a highly variable phenotype and is difficult to distinguish from other closely related species.
Reduces atopic dermatitis
In a meta-analysis of eight clinical trials, a study of the probiotic Lactobacillus planetarium reduced the incidence of atopic dermatitis (AD) in infants. However, the study found no benefits from probiotics containing Bifidobacterium. While there is no conclusive evidence to support these findings, the small number of participants and heterogeneity of the studies should be interpreted with caution. Moreover, most studies were conducted on infants and only followed patients for a limited period. Still, the study showed significant improvements in children compared to placebos.
In the current meta-analysis of the available clinical trials, the authors found that oral probiotics can significantly reduce the severity of atopic dermatitis. Further, they noted that more trials should be conducted to establish the exact magnitude of the benefit. The authors report no conflicts of interest and gratefully acknowledge the Pontificia Universidad Catolica del Ecuador for its support of this study.
In addition to reducing atopic dermatitis symptoms, the bacterium Lactobacillus casei has other benefits. It is associated with suppressing inflammation and skin sensitivity and has a protective effect on atopic dermatitis. Additionally, it is associated with increased levels of L. acidophilus, Propionibacterium, and Corynebacterium in the skin.
Reverses glucose intolerance
Probiotics, such as Lactobacillus planetarium, have positive effects on the host’s health when given in sufficient amounts. These bacteria have been shown to improve immune function, reduce oxidative stress, and even alleviate the symptoms of T2DM. In addition, probiotics have been shown to improve glucose tolerance in patients with T2DM. The research results in this article show that Lactobacillus Plantarum HAC01 has positive effects on both T2DM and hyperglycemia.
The fermentation process of lactobacillus plantarium in rats has shown significant effects on reversing glucose intolerance. The fermentation of barley with this probiotic has also been shown to ameliorate insulin levels and reduce total cholesterol and triglycerides. Furthermore, this probiotic has been shown to improve urinary and hepatic functions in postmenopausal women and rats with T2D.
One study showed that the gut microbiota of mice treated with lactobacillus plantarium HAC01 decreased blood glucose and improved glucose intolerance. It also activated the AMPK and Akt pathways in the liver, restored the gut microbiota, and increased butyric acid levels. Furthermore, L. Plantarum improved hyperglycemia and T2DM, restoring the gut microbiota’s balance and alleviating symptoms of both conditions.
In addition, the effects of Lactobacillus Plantarum K68 on visceral fat pads were reduced, and inflammatory factors were inhibited. In this study, mice were fed a normal fat diet for ten weeks and supplemented with lactobacillus plantarium strains 1 x 108 CFU per mouse daily. Adipocyte size was also reduced after the Lactobacillus planetarium treatment, while insulin levels decreased. The elevated HbA1c levels were controlled in both groups.
Reverses irritable bowel syndrome
Probiotics and their beneficial effects on irritable bowel syndrome are discussed in several recent studies. These studies have shown that Lactobacillus planetarium (L. Plantarum) 299v can relieve symptoms of irritable bowel syndrome and improve colonic motility. Researchers have studied several Lactobacillus strains in people with irritable bowel syndrome studies. A recent study investigated the effects of lactobacillus plantarium on colonic inflammation and motility. The study used oil of mustard and lactobacillus plantarium 299v as a probiotic to treat mice with irritable bowel syndrome. The study also looked at the release of colonic interferon-gamma.
In mice, lactobacillus plantarium 299v significantly reduced the level of inflammatory markers and normalized intestinal transit rates. These effects were evident in the oil of mustard murine IBS model. These findings suggest that L. Plantarum can reverse irritable bowel syndrome. Further studies are needed to confirm the effectiveness of this probiotic in humans. Once approved, it is now available in prescription and over-the-counter formulations.
In humans, lactobacillus plantarium CCFM1143 can reverse the symptoms of irritable bowel syndrome by repopulating the gut microbiota. The study also demonstrated that lactobacillus plantarium CCFM1143 improves the gut microbiota of patients with IBS. A statistical analysis of the study showed that lactobacillus plantariumCCFM1143 reduced inflammatory bowel disease and had no adverse effects. However, several studies are needed to determine whether Lactobacillus Plantarum can reverse irritable bowel syndrome in chronic cases.
Promotes collagen synthesis
Human fecal isolates of lactobacillus plantarium were studied to evaluate their hydrophobicity, adhesion capability, and colonization potential against immobilized type I collagen. Among these isolates, four were found to have the highest degrees of hydrophobicity and a high degree of adhesion to collagen. Furthermore, the Lp91 strain displayed the highest level of hydrophobicity and was more adherent to type I collagen.
The growth of these bacteria was determined using milkfish extracts and beef hide. They were able to hydrolyze the collagen proteins in the hide. The growth of these bacteria is a good indication that the strain can potentially become a bio-hydrolyzer and play an important role in the food industry. Further, the bacteria can break down proteins in other plant and animal sources, including milk, veal, and eggs.
Cultures of lactobacillus plantarium were tested for their ability to bind to collagen in vitro quantitatively. Agar plates containing 200 mL of the strain were used for the test. After that, cells were harvested and resuspended in 20 ml of 2 M Guanidine-HCL. The cells were incubated for two h at 37 degC. Then, they were dialyzed against water at four degC.
To test whether Lactobacillus planetarium promotes collagen synthesis, the researchers isolated RNA from the early to the mid-exponential phase of bacterial cultures. They studied three different strains with high collagen-binding ability. The integrity and purity of each RNA preparation were verified using an agarose gel electrophoresis (SDS-PAGE) and spectrophotometry. Finally, first-strand cDNA was synthesized from 1 mg of RNA using a specialized protocol developed by the manufacturer of Fermentas. Then, diluted five times, the samples were transferred to nitrocellulose membranes for Western blot analysis.
There are several health benefits of using probiotic bacteria, including the fact that they lower cholesterol levels. They may be the natural solution to hypercholesterolemia and the associated cardiovascular disease. The species most frequently studied for cholesterol-lowering effects is Lactobacillus Plantarum, and its best-known strain is Lp299v. Although different strains of this bacterium have distinct effects on cholesterol levels, studies have shown that several of these bacteria can reduce LDL and total cholesterol levels in the body.
In one study, researchers isolated and cultured three strains of lactobacillus plantarium and three L. paracasei. The two Plantarum strains significantly reduced cholesterol levels in MRS broth, reducing cholesterol levels by an average of 19.4% and 6.8%, respectively. These bacteria maintained their cholesterol-lowering activity in the presence of cholesterol-lowering compounds, ranging from 5.0% to 8.2%. The bacteria were able to survive in both biliary and acidic environments and were also capable of surviving in the presence of fat. The scientists also noted that L. Plantarum strains could survive in the presence of bile and gastric acid, making them ideal for use in supplements.
The ECGC 13110402 study examined the effects of Lactobacillus Plantarum in healthy adults and those with mild hypercholesterolemia. As with any medical study, you were participating in a clinical study is a personal one. Discuss any potential risks and benefits with your family and friends. Study research staff members can provide more information about a particular clinical study. If you are interested, you can contact the study researchers directly.