Lactobacillus Helvetica, also known as L. helveticus, is a rod-shaped bacterium that produces lactic acid. This bacteria is most commonly used in American Swiss and Emmental cheese manufacture. The bacteria have a variety of health benefits, including increased bioavailability of specific nutrients. In addition, it is believed to have some antitumor, antiallergenic, and antihypertensive properties.
Increased bioavailability of specific nutrients
Research shows that L. helveticus improves the bioavailability of specific nutrients. The bacteria also exhibit beneficial immunomodulatory properties. Its enzymes enhance the bioavailability of certain nutrients in the gut. These bacteria can produce bioactive peptides by degrading proteins from food. Its health benefits are numerous, and it can improve the quality of foods that we eat.
The fermentation of milk containing L. helveticus decreased the antigenicity of whey proteins in mice. In a double-blind, crossover study, the peptide content of L. helveticus was increased in the intestines of mice treated with fermented milk. In the second part of the study, peptides produced by the bacteria were compared to those produced by the control group.
Some Lactobacillus strains increase absorption of Vitamin D in humans. Some have a phytase enzyme that breaks down phytates in the gut during fermentation. Other strains have no phytase activity, but they increase the bioavailability of iron in mice. The strain can colonize the gut and increase the bioavailability of specific nutrients. It also contains mucin, an enzyme that binds iron.
The bacteria in the human intestine help digest fat. A lowered availability of bile means the liver must absorb more cholesterol. Researchers believe that L. helveticus increases absorption of Niemann-Pick C1-Like 1 (NPC1L1), a major protein involved in intestinal cholesterol absorption. While these findings are not confirmed in humans, they are based on the studies performed on mice.
Modest antihypertensive effect
There are several benefits of lactobacillus Helvetica. The fermentation of soy proteins may increase their isoflavone aglycone content, which may have an antihypertensive effect. A 12-week feeding trial with 30 spontaneously hypertensive rats found that Val-Pro-Pro significantly reduced systolic blood pressure by 17 mm Hg compared to placebo-treated rats. Its antihypertensive effect was modest and dose-dependent but was significant for lowering SBP and DBP.
Fermented milk has an antihypertensive effect in animal models and humans. It has been studied extensively for its putative antihypertensive effect. Miguel et al. found that Enterococcus faecalis-fermented milk significantly decreased blood pressure and increased plasma renin activity. Furthermore, Lactobacillus helveticus contains biologically active peptides, which may reduce blood pressure in hypertensive patients.
There are several studies examining the effects of lactobacillus on blood pressure. These studies show that probiotics have a modest antihypertensive effect in human subjects. The antihypertensive effect of Lactobacillus helveticus was most evident in patients with high BP and obese subjects. Although the results are still conflicting, they support the concept that probiotics have some antihypertensive effects on blood pressure. However, no studies have examined the effects of pure probiotic biomass on blood pressure levels.
Studies have shown that probiotics can modulate lipid profiles, insulin resistance, renin levels, and other important physiological processes. They have antihypertensive effects in healthy subjects and have the potential to improve the overall health of hypertensive individuals. The effect of probiotics may be further attributed to their ability to modulate lipid profiles and insulin levels.
Modest antiallergenic effect
The fermentation product of Lactobacillus helveticus, L. helveticus isolate H9, has moderate antiallergenic effects. The lactic acid produced by L. helveticus inhibits the converting enzyme angiotensin I and is a potent antimicrobial agent. This bacteria may have additional benefits, such as anti-inflammatory and immunostimulant effects.
A recent study evaluated the effects of L. helveticus-fermented milk whey on intact skin and SDS-exposed skin. Mice were fed 10% L. helveticus-fermented milk whey in distilled water for five weeks, and then SDS was applied to the dorsal skin of these mice at four weeks. Dermatitis developed after this treatment, and transepidermal water loss and skin sizes were assessed.
In a study involving postmenopausal women, L. helveticus improved calcium metabolism and decreased parathyroid hormone levels, a hormone associated with bone loss. In a study published in Frontiers in Microbiology, L. helveticus has a moderate antimicrobial effect in inflammatory bowel diseases, including colitis. In another study, mice fed with L. helveticus-fermented milk showed improved learning and recognition test performance. The researchers also found that mice fed with L. helveticus-fermented milk product had reduced splenocyte production. This suggests that L. helveticus may have a positive antiallergenic effect on various symptoms associated with arthritis.
The LAB consortium has shown remarkable stability in rye sourdough. The sourdough was adapted to the sourdough environment through lyophilization. The resulting sourdough had significant levels of Lactobacillus helveticus, a dominant species. This microbial consortium can be used to prevent or treat atopic disease in infants and children.
Modest antitumor effect
The population structure of Lactobacillus helveticus isolates isolated from naturally fermented milk products is not fully understood, but studies suggest that these bacteria have a modest antitumor effect. They also have a role in regulating inflammatory and neuroinflammatory diseases, including cardiovascular disease. The antitumor effect of Lactobacillus helveticus may result from other beneficial effects that the bacteria produce.
Recent studies have shown that L. helveticus reduces the absorption of certain mutagens. In vitro studies have shown that L. helveticus inhibits the growth of prostate cancer cells in a dose-dependent manner. It has also been found to reduce disseminated systemic Candida albicans in an immunodeficient mouse model. Furthermore, the freeze-dried Lactobacillus isolates reduced tumors in mice induced with colon cancer.
Long-term use of a heat-killed strain of Lactobacillus helveticus MCC1848 has been reported in Japan. In the same study, the bacteria had an antitumor effect on mice that underwent chemotherapy. This is a promising sign for a potential new treatment for cancer. However, further research is necessary to understand how probiotics affect the vagus nerve and how this effect is mediated.
Aside from preventing tumor growth, Lactobacillus helveticus has also been found to have a protective effect against atopic disease. Its antitumor effect has been further supported by discovering that Lactobacillus helveticus is the dominant species in industrial rye sourdough. This strain is considered a good alternative starter.
Inhibition of pathogenic microorganisms by L. helveticus
Research has shown that L. helveticus has several beneficial health effects, including enhancing the bioavailability of nutrients, improving gut microbiota, modulating the immune system, and generating bioactive peptides from food molecules. These properties make it a promising alternative treatment for various enteric infections. In a recent study, researchers found that lactobacillus strains of Grana Padano can inhibit the growth of Streptococcus pyogenes, the etiological agent of sore throat and acute rheumatic fever.
L. helveticus inhibits several pathogenic microorganisms, including E. coli O157:H7. The bacteria exert their antimicrobial activity on various host tissues, including the intestine, vagina, and pharynx. Its antimicrobial activity can be enhanced by pre-treatment with the bacteria.
The bacterium was isolated from MRS broth and McFarland solution and incubated for 24 hours at different pH levels. Molecular typing showed a wide range of pH tolerance. The phage isolates LBh5 and LBh1 showed significantly greater tolerance to high pH than L. Plantarum. However, the two strains were not equally effective against pathogenic bacteria.
The enzyme L. helveticus produces an ace inhibitory peptide (ACE)-inhibitory peptide. It has the highest capacity to produce ACE inhibitory peptides from food proteins. This activity is thought to be responsible for the inhibition of pathogenic microorganisms. This ability is the reason why L. helveticus inhibits so many pathogenic microorganisms.