Lactobacillus Bulgaricus | 3 Important Points

Lactobacillus Bulgaricus

Lactobacillus Bulgaricus

Lactobacillus bulgaricus was obtained from the DSMZ, Germany. It was cultured in MnSO4*4H2O, 0.05 g/L, and Tween 80. This culture medium is used for regular cultivation. The resulting culture contains approximately 104 b.c. L of bacteria. It is also known as IMAU90010.


The KLDS 1.0207 strain of Lactobacillus bulgaricus was recently tested for its ability to restore gut microbiota in mice. Compared to other strains of L. bulgaricus, this strain showed a relatively low loss of viability at pH 1.5 and pH 3.0 and showed high viability at pH 2.5. Despite the promising results of this study, further research is needed to validate these preliminary findings.

The subspecies L. bulgaricus is one of the most commonly used starter cultures in industrial fermented dairy production. However, it is also found in many naturally fermented foods, which may offer useful information for improving industrial starter cultures. Sequence data of 251 confirmed strains of L. bulgaricus were analyzed using multilocus sequence typing based on eight conserved genes. This type of sequence analysis revealed 106 distinct subs—bulgaricus strains, with most belonging to one of five clonal complexes.

The genetic diversity of subsp. bulgaricus is quite diverse, with different isolates occurring in different regions of China. The Mongolian strains were found in the QSG, South-west Russia, and Xinjiang provinces. Of these, 86 percent were in the CC1, which exhibited the highest diversity, consisting of 19 STs and 123 strains. The subs. bulgaricus was found across a greater area than other types, including South-west Russia and Xinjiang, which suggests the strain’s strong adaptability to diverse niches.

Further study is needed to confirm the subsp—bulgaricus KLDS 1.0207 as a potential bio-preservative. This study suggests that the strain may be a viable candidate for use as a bio-preservative in the food industry. While the results are promising, further characterization of these acid metabolites will be necessary to confirm the strain’s potential as a food ingredient.

Some consumers may experience allergic reactions when taking Lactobacillus acidophilus and bulgaricus. Although these are rare, they can occur. People with allergies to soy products and lactose intolerance should not take these supplements. The FDA recommends that people take Lactobacillus acidophilus and bulgaricus supplements with caution. However, you should follow all instructions and consult your doctor or herbal supplement provider before using the product.

This strain is a subspecies of Lactobacillus delbrueckii. It is also used in yogurt. It grows on China Blue Lactose Agar. It is a transient probiotic. It benefits the gut environment as it passes through the digestive system. It may be beneficial to your health. If you suffer from any of these conditions, it may be good to consider taking Lactobacillus bulgaricus IMAU90010.

In addition to being effective against bacteria that cause bacterial vaginosis, L. bulgaricus KLDS 1.0207 also has an antimicrobial effect against G. vaginalis ATCC14018. The CFS from L. bulgaricus KLDS 1.0207 has the potential to have application in the medical industry. It would be best to confer with your doctor about any precise conditions you may be suffering from.


The strain of Lactobacillus bulgaricus used in industrial fermented dairy production was first identified by the Bulgarian doctor Stamen Grigorov in 1905. The LAB strain is also common in natural dairy products. It may provide useful information for improving industrial starter cultures using a multilocus sequence typing method based on eight conserved genes, 106 distinct subsp. bulgaricus sequence types were identified in 251 confirmed strains. Most were assigned to five distinct clonal complexes.

The third CDM was developed for L. bulgaricus strain NCFB2772. In this CDM, the growth rate was 0.2 h-1, which is three times lower than the growth rate in complex media, including milk and MRS. This new CDM meets the criterion for efficient growth in a broad range of conditions, and all of the strains grew in it.

The geographical distribution of the subsp. bulgaricus strain in China is a smidgen of the diversity of this species. Moreover, the genetic structure of the CCs is unequal and has six lineages, characterized by different rates of homologous recombination. The L1 and L6 strains were found throughout a wider range, including South-west Russia, Xinjiang, and a region in China called QSG. This implies a high level of adaptive evolution in various niches.

These data also suggest that the L. bulgaricus IMAU90013 is a candidate for the next starter strain in industrial fermented dairy production. However, the strain’s availability is limited, and further research is needed to confirm its efficacy. Once again, this is a good indicator for the future of industrial fermentation. So, if you want to make your yogurt, consider trying it.

LABs contain friendly bacteria that reduce the growth of unhealthy bacteria in the digestive tract. Lactobacillus bulgaricus is a transient probiotic that helps preserve the gastrointestinal environment while passing through it. The beneficial effects of the LABs can be measured by measuring the number of LABs in the final product. However, it is important to note that probiotics are not a panacea for digestive issues.

The most common type strain of L. bulgaricus is L. bulgaricus IMAU90013, and its allele profile is provided in Supplementary Table S2. The most common subsp. bulgaricus strains are assigned to five clonal complexes (CC) by eBURST analysis. CC1 contains almost half of all strains (n = 123) and consists of 19 STs. ST10 was predicted to be the group founder. CC2 contained 18 strains in nine STs, while ST41 had five days.

Another probiotic supplement, L. bulgaricus, is used to treat lactose intolerance. Lactose is a sugar found in milk broken down by an enzyme called lactase. When lactase is deficient, it results in unpleasant gastrointestinal symptoms and is known to cause digestive discomfort. Lactobacillus bulgaricus is thought to break down lactose and ease the symptoms of lactose intolerance.

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Lactobacillus bulgaricus


The name Lactobacillus bulgaricus is an abbreviation for the strain of LAB found in yogurt. Lactose is the sugar found in milk and is broken down by an enzyme called lactase. Lactose intolerance is characterized by gastrointestinal symptoms and can be relieved with this strain. It is found naturally in dairy products and may help improve the industrial starter cultures.

This probiotic supplement contains both L. acidophilus and L. bulgaricus strains and is commonly sold as an herbal supplement. Since herbal supplements do not have regulated manufacturing standards, many have been contaminated with toxic metals and other drugs. These products may also contain ingredients that are not considered healthy and should not be used by people with food allergies or lactose intolerance.

The geographical distribution of subsp. bulgaricus strains are unbalanced. The three lineages were associated with specific geographic regions, suggesting adaptive advantages within the locality. The L1 and L6 STs are half Mongolian and half Xinjiang. These findings suggest that gene transfer has occurred in the subsp—bulgaricus evolutionary history.

Genetic diversity analysis of subsp. bulgaricus strains revealed SNPs in eight housekeeping genes. These genes encode the ATP-dependent protease ATP-binding subunit ClpX, chromosomal replication initiation protein dnaA, and CTP synthetase. Furthermore, the subsp. bulgaricus strains also displayed high allelic diversity.

The allelic profiles of all 251 subsp. bulgaricus strains were analyzed to identify their phylogenetic relationships. Allele profiles of the strains were listed in Supplementary Table S2. The eBURST analysis identified five clonal complexes (CCs) and assigned them to one of them. CC1 consisted of almost half of all strains and was divided into 19 STs. Among these, ST10 was predicted to be the group founder. CC2 was made up of 18 strains in nine STs. CC2 contained 18 strains, and ST41 had five days.

In the present study, L. bulgaricus IMAU94251 is closely related to L. delbrueckii. The authors’ analysis also considered the genetic diversity of the subspecies. While the type strains were included for reference, the results were limited. It is not known whether the subspecies are genetically related to each other. There are several other subspecies, but the subsp. bulgaricus strains exhibit a high degree of similarity among the strains.

Lactobacillus Bulgaricus | 3 Important Points

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